| |
Experimental Biology 2009
(AAA, APS, ASBMB, ASIP, ASN,
ASPET)
Saturday April
18-Wednesday April
22, 2009
New Orleans, LA
Abstract Deadline:
November 5, 2008
ASPET Program
Photos courtesy of New Orleans
Convention & Visitors Bureau
ASPET
Program
Saturday, April
18
12:30 - 3:00 PM
2009
Teaching Institute:
Threading New Concepts into Existing Curriculum: Experiences with Genomics
Chair: George A. Dunaway
Convention Center, Room 207
Curricular threads in medical school curricula.
Phillip R. Musich, East Tennessee State University
Experience with introduction of genomics into medical biochemistry.
Phillip R. Musich, East Tennessee State University
Experience with introduction of genomics into medical pharmacology.
George A. Dunaway, Southern Illinois University
Development and use of clinical scenarios to introduce pharmacogenomics.
George A. Dunaway, Southern Illinois University
Resources for learning and curricular integration of genomics.
Phillip R. Musich, East Tennessee State University
Diversity
Committee Symposium:
ASPET Travel Fellows: Lessons Learned Along the Way:
Career Choices from
Past Travel Awardees
Chairs: Gonzalo E. Torres and Dolores Shockley
Convention Center, Room 208
The goal of this symposium is to present
and discuss career options taken by past fellows and travel awardees. The
stories are of scientists who made the decision to either stay in academia or
leave academic research and forged paths to alternative career options related
to science. These stories will focus on how these scientists got to where they
are today and what they have learned along the way. After the talks, there will
be an open session with questions and discussion from the audience.
Career options in science.
Gonzalo E. Torres, University of Pittsburgh
A career path outside the bench as a medical science liaison.
Shola Adewale, Eisia Inc.
Scientific regulatory and policy writing in the government: Desktop, an
alternative to benchtop.
Michelle D. Walker, Drug Enforcement Administration
Career opportunities in biomedical research: The academic perspective.
Chantal A. Rivera, Louisiana State University Health Sciences
Center
Closing remarks
Dolores C. Shockley, Meharry Medical College
Saturday, April
18
3:15 - 5:45 PM
Graduate
Student-Postdoctoral Colloquium:
Mentoring: It Goes Both Ways
Chair: Sarah H. Lindsey
Convention Center, Room 209
The success of graduate or
post-graduate research experiences depends largely on a positive relationship
between the trainee and mentor. This colloquium, based on a program developed
by Chris Pfund at the Wisconsin Program for Scientific Teaching, is focused on
helping participants improve the efficiency and effectiveness of their current
mentor/mentee relationship and learn how to become effective research mentors
themselves. Discussions will focus on different mentoring styles and strategies
for developing confidence and independence, establishing expectations and
improving communication skills.
Entering mentoring: Learning to become an effective research mentor.
Chris E. Pfund, University of
Wisconsin Program for
Scientific Teaching
Session 1: Learning to communicate
Session 2: Goals and expectations
Session 3: The elements of good mentoring
Pulling it all together: Pharmacologists helping pharmacologists.
Stephanie Watts, Michigan State University
Sunday, April 19
8:50 - 9:20 AM
Ray Fuller Lecture in the Neurosciences
Convention Center, Room 206
Introduction. Joe A. Beavo
Henry A.
Lester, Caltech
Changes in the
Brain During Chronic Exposure to Nicotine
Sunday, April 19
9:30 - 12:00 PM
RAY FULLER SYMPOSIUM:
Mechanisms of Nicotine Addiction
Chair: Henry A. Lester
Convention Center, Room 206
Preceded by the Ray
Fuller Lecture in the Neurosciences
Genome-wide
association scans and candidate genes in nicotine addiction.
Laura S. Bierut, Washington University
Signal transduction pathways in nicotine addiction.
Darlene Brunzell, Virginia Commonwealth University
The Ubiquitin-proteasome pathway in nicotine addiction.
Mariella De Biasi, Baylor College of Medicine
Imaging studies of neural substrates in nicotine addiction.
Edythe D. London, UCLA
Workshop: Integrating Basic Sciences
and Patient Care in a Core Clerkship Curriculum
(Sponsored by the Divisions for Pharmacology
Education; Cardiovascular Pharmacology; and Systems &
Integrative Pharmacology)
Chair: Amy
Wilson-Delfosse
Convention Center, Room 208
Integrating basic and clinical sciences in the post-gateway era.
Frazier Stevenson, UC, Davis
Building integration in a new medical school: University of Central
Florida College of Medicine.
Lynn M. Crespo, University of Central Florida
Integrating basic sciences and patient care in Western Reserve2.
Amy L. Wilson-Delfosse, Case Western Reserve
University
Design of an integrative case: Small Group Discussions
Discussants: Amy Wilson-Delfosse, Case Western Reserve
University
James P. Bruzik,
Case Western Reserve University
Lynn M. Crespo, University of Central Florida
Frazier Stevenson,
UC, Davis
Small group presentations and panel discussion.
AMPK as a Novel
Therapeutic Approach for the Treatment of Metabolic Disorders and
Heart Disease
(Sponsored by the Division for Cardiovascular Pharmacology and ASBMB)
Chairs:
Kenneth B. Walsh and Benoit Viollet
Convention Center, Room 207
Targeting AMPK as a novel therapeutic approach for the treatment of
metabolic disorders.
Benoit Viollet, University of Paris
Cardioprotective effects of adiponectin are mediated in part through
AMPK.
Kenneth Walsh, Boston University School of Medicine
AMPK activation as a strategy for protecting vascular endothelial
function.
Ming-Hui Zou, University of Oklahoma Health Science Center
AMPK activation projects the failing diabetic heart.
David J. Lefer, Emory University
Adiponectin induces vascular smooth muscle cell
differentiation via AMPK (Abstract 577.11)
M. Ding, R.J. Wagner, K.M. Fetalvero, Z. Kasza, R.J. Powell, K.A.
Martin, Dartmouth College
Metabolic and structural remodeling of heart-derived H9c2 cells
by AMPK activation (Abstract 577.10)
J.M. Dai, R. Saeedi, V. Sharma, V. Saran, H. Parsons, J. Dyck, M.
Allard, University of British Columbia & University of
Alberta
Advances in
Down Syndrome Neuroscience Research: Implications for
Alzheimer's Disease, Dementias and Other Cognitive Disorders
(Sponsored by the Divisions for
Neuropharmacology; Behavioral Pharmacology; Drug Discovery, Drug
Development, & Regulatory Affairs; Molecular Pharmacology; and
Systems & Integrative Pharmacology)
Chairs:
Tim A. Esbenshade and Alberto Costa
Convention Center, Room 210
Down syndrome: A genetic disorder in biobehavioral
perspective.
Lynn Nadel, University of Arizona
Human chromosome 21/Down syndrome gene function:
Implications for cognitive development and Alzheimer's disease.
Kathleen Gardiner, University of Colorado Denver in
Aurora
Structural and functional changes at the synapse associated with
Down syndrome and Alzheimer's disease
Craig C. Garner, Stanford University
Evidence for NMDA receptor dysfunction in Down Syndrome:
implications for a potential pharmacotherapy
Alberto Costa, University of Colorado Health Sciences
Center
A
Renaissance in Marine Pharmacology: Preclinical Curiosity to
Clinical Reality
(Sponsored by the Divisions for Drug Discovery, Drug Development & Regulatory
Affairs and Systems & Integrative Pharmacology)
Chairs: Keith
B. Glaser and Alejandro M. Mayer
Convention Center, Room 209
Marine-sourced
secondary metabolites as leads to drugs.
David J. Newman, NCI, Frederick
A fresh pipeline of marine natural product leads for the
control of neuroinflammation and depression
Mark M. Hamann, Triton Biopharma
Conus
peptides: How snail compounds can win the race.
J.
Michael McIntosh, University of Utah
Harnessing marine natural products for drug discovery: Pragmatic
marine microbiology.
Guy T. Carter, Wyeth
Research
The pseudopterosins – Investigation into their mode of action.
Claudia E. Moya, University of California, Santa Barbara
The
global marine pharmacology pipeline: Compounds with
anti-infective, immune, anti-inflammatory and CNS activity.
Alejandro M. Mayer, Midwestern University
Sunday, April 19
2:00 - 2:50 PM
IUPHAR Lecture
Convention Center, Room 206
Introduction: S.J. Enna
Seven
Transmembrane Receptors
Robert J.
Lefkowitz, Duke University
Sunday, April 19
3:00 - 5:30 PM
Metabolomics
in the Search for Biomarkers for Human Diseases
(Sponsored by the Divisions for Clinical
Pharmacology, Pharmacogenomics & Translational Medicine; Drug
Metabolism; Molecular Pharmacology; and ASBMB)
Chairs: Frank J. Gonzalez and Richard B. Kim
Convention Center, Room 207
Metabolite profiling.
Oliver Fiehn, University of California, Davis
Metabolomics
identifies perturbations in human disorders of propionate
metabolism.
William R. Wikoff, The Scripps Research Institute
Metabolomics in biomarker discovery: Future uses for cancer
prevention.
Young Kim, NCI, NIH
Pharmacometabolomics
Andrew D. Patterson, NCI, NIH
LC-MS-based metabolomics of acetaminophen-induced acute
toxicity (Abstract 760.4)
C. Chen, K.W. Krausz, Y.M. Shah, J.R. Idle, F.J. Gonzalez, University
of Minnesota, St. Paul and NCI, NIH, and Charles University,
Czech Republic
The
Serotonin Transporter: Not Just for Neurons Anymore
(Sponsored by the Divisions for Cardiovascular Pharmacology;
Clinical Pharmacology
Chair: A. Elizabeth Linder and Stephanie W. Watts
Convention Center, Room 206
Plasma
serotonin levels and the platelet serotonin transporter.
Fusun Kilic, University of Arkansas for Medical Sciences
5-HT, 5-HT receptors and SERT in the pulmonary circulation.
Barry L. Fanburg, Tufts University School of Medicine
5-HT uptake in the peripheral vasculature: Focus in veins.
A. Elizabeth Linder, Michigan
State University
A role for 5-HT in the immune response.
John Gordon, University of Birmingham, United Kingdom
Beyond Prozac: generation and characterization of SSRI
insensitive transgenic mice (Abstract 942.7)
B.J. Thompson, T. Jessen, L.K. Henry, K.L. Gamble, P.J. Chisnell, D.G.
McMahon, R.D. Blakeley, Vanderbilt University
Chronic serotonin infusion leads to prolonged fall in blood
pressure in the spontaneously hypertensive rat (Abstract 932.2)
R.P. Davis, T. Szasz, E. Linder, R. Burnett, S.W. Watts,
Michigan State University
Generating
Proteomic Diversity in Xenobiotic Biotransformation with Alternative
RNA Splicing
(Sponsored by the Divisions for Toxicology; Drug
Metabolism; and Molecular Pharmacology)
Chair: Curt J. Omiecinski
Convention Center, Room 208
Genome
wide analysis and heritability of alternatively spliced transcripts
in humans.
Jacek Majewski, McGill University
Small molecule approaches for dissecting the structure and
function of the RNA spliceosome.
Melissa S. Jurica, UC, Santa Cruz
Correcting aberrant splicing patterns in human disease genes
with cell penetrating morpholino oligonucleotides.
Patrick L. Iverson, AVI Biopharma, Inc.
Aberrant splicing of human P450 genes as a modifier of drug and
chemotherapeutic metabolism.
Ulrich M. Zanger, Dr. Margarete Fischer-Bosch Inst of
Clinical Pharmacology, Stuttgart
Alternative splicing of the human xenoreceptor, CAR, results in
distinct receptor subtypes with unique biological activities.
Curt J. Omiecinski, Penn State University
Emerging
Approaches to Treatment of Alzheimer’s Disease
(Sponsored by the Divisions for Behavioral Pharmacology; Drug
Discovery, Drug Development & Regulatory Affairs; Neuropharmacology: and Systems
& Integrative Pharmacology)
Chairs: Randy Strong and Greg A. Gerhardt
Convention Center, Room 210
Current
status of treatment of Alzheimer’s and related neurodegenerative
diseases.
Randy Strong and Greg A. Gerhardt, University of Texas Health Science
Center Barshop Institute for Longevity & Aging
Studies & University of Kentucky
Understanding angiogenic dysregulation in Alzheimer’s
disease: opening the door for new therapeutic strategies in AD.
Gregory A. Jicha, University of Kentucky
Pathways of amyloid-beta toxicity: Potential novel targets
for intervention in Alzheimer’s disease.
Veronica Galvan, The Buck Institute for Aging
Research
The effect of anti-Aß interventions on tau pathology.
Salvatore Oddo, University of Texas Health Science
Center, San Antonio
Steroid hormone receptor signaling and Alzheimer’s disease.
Meharvan Singh, University of North Texas Health
Science Center, Fort Worth
Pharmacology Education Division Workshop:
Using Human Patient Simulators to Enhance Pharmacology Education
Throughout the Undergraduate Medical Curriculum
Chair: John
L. Szarek
Simulation has
been a mainstay in graduate medical education, but only recently has
it become more common in undergraduate medical education. This
workshop will help pharmacology faculty learn how simulation using
patient simulators can be used as part of their repertoire of
learning modalities for medical students in the first two years and
beyond. The workshop will include didactic and hands-on activities
on simulation modalities, the rationale for the use of simulation,
simulation as a complement to the basic science curriculum, and
scenario construction and debriefing.
Hands on
experience using a human patient simulator.
Facilitators: John L. Szarek, AT Still
University and Robert J. Theobald, Jr., AT Still
University, Kirksville, MO
The rationale
for the use of simulation as a complement to the basic science
curriculum.
John L. Szarek, AT Still University
Scenario construction and debriefing.
Susan Pasquale,
University of Massachusetts Medical School
Adoption and implementation strategies (and coping strategies
for dealing with barriers) that could be used to support using
simulation for teaching pharmacology throughout the undergraduate
curriculum.
William B. Jeffries, Creighton University School of Medicine
Sunday, April 19
3:30 - 6:30 PM
Membrane Proteins as Drug Targets
(Organized by ASBMB and co-sponsored by ASPET)
Chair: W.A. Henderson
Convention Center, Room 352
Crystal structure of SGLT
reveals mechanisms of Na+/sugar co-transport
(Abstract 92.1)
J. Abramson, UCLA
Filling the gap: aA streamlined approach for
monitoring expression and purification of membrane proteins with
a periplasmic C-terminus via GFP fluorescence (Abstract 698.4)
J.M. Hsieh, G.C. Mercado, H-Q. Bui, J. Abramson, UCLA
Pharmacological probes for AMPA receptors (Abstract 92.2)
P.M. England, UCSF
Crystal structure of the murine voltage dependent anion
channel 1 at 2.3 Ĺ resolution (Abstract 698.5)
R. Ujwal, D. Cascio, J-P. Colletier, S. Faham, J. Zhang, L. Toro, P.
Ping, J. Abramson, UCLA
Phenylalanine 508 forms an intra-domain contact crucial for
CFTR folding and dynamics (Abstract 698.7)
BA.W.R. Serohijos, R. Hegedus, A. Aleksandrov, L. He, L. Cui, J.R.
Riordan, N.V. Dokholyan, University of North Carolina
at Chapel Hill
Cys-loop ion channels and G-protein coupled receptors as
targets for structure-inspired drug discovery (Abstract 92.3)
W.A. Hendrickson, HHMI, Columbia University
Monday, April 20
8:30 - 9:20 AM
JULIUS AXELROD LECTURE
Convention Center, Room 206
Introduction: Susan G. Amara
Miscarriage at the Synapse: Brain Disorder-associated
Deficits in MembraneTransport
Randy D. Blakely,
Vanderbilt University
Monday, April 20
9:30 - 12:00 PM
JULIUS AXELROD SYMPOSIUM:
The Neurotransmitter End Game: Structure, Function and Regulation of
Neurotransmitter Transport
Chairs: Randy D. Blakely and Maureen K. Hahn
Convention Center, Room 206
Preceded by the
Julius Axelrod Lecture
The end of cannabinoids as we know it: Molecular control of anandamide
inactivation.
Eric L. Barker, Purdue School of Pharmacy
Cocaine (target) trafficking: Dopamine transporters.
Haley E. Melikian, University of Massachusetts Medical School
Hugging Prozac: How serotonin transporters recognize
antidepressants.
L. Keith Henry, University of North Dakota School of Medicine and
Health Sciences
Reading the labels: How phosphorylation modifies serotonin
transport.
Sammanda Ramamoorthy, Medical University of South Carolina
Nothing sweeter than DAT: How insulin controls the dopamine
transporter.
Aurelio Galli, Vanderbilt University
Regenerative Pharmacology: The New Pharmacology
Sponsored by the Divisions for Pharmacology
Education and Systems & Integrative Pharmacology; Drug Discovery,
Drug Development & Regulatory Affairs)
Chairs: George J. Christ and Jack W. Strandhoy
Convention Center, Room 209
Introduction: State of regenerative pharmacology.
George J. Christ, Wake Forest University Baptist
Medical Center
Drug delivery technologies for regenerative pharmacology.
Grace Lim, Kyunpook National University, Korea
Bio-inductive scaffolds and regenerative nanomaterials for tissue
engineering.
Mark A. Van Dyke, Wake Forest University Baptist
Medical Center
Tubular cardiovascular engineering: Developmental pharmacology of
muscle, vessel and valves.
Richard L. Goodwin, University of South Carolina
Regeneration of a complete urinary bladder with an autologous
neo-bladder replacement construct - structural, functional and
pharmacological characterization.
Tim Bertram, Tengion, Inc.
MicroRNAs
as Biological Effectors and as Pharmacological Targets in the
Cardiovascular System
(Sponsored by the Divisions for Molecular
Pharmacology; Clinical Pharmacology, Pharmacogenomics &
Translational Medicine; Cardiovascular Pharmacology; Drug Discovery,
Drug Development & Regulatory Affairs; Systems & Integrative
Pharmacology; and ASBMB)
Chair: J. David Port
Convention Center, Room 207
Role of miR-208 in regulating the expression of myosin heavy chain genes.
Eva van Rooij, University of Texas Southwestern Medical
Center
Correlation between miRNA and mRNA expression in heart failure.
J. David Port, University of Colorado Health Science Center
miRNA regulation of angiotensin receptor expression.
Terry Elton, The Ohio State University
miR and mRNA profiles in clinical and experimental heart disease
Gerald W. Dorn II, Washington University
The Role of
Nuclear Receptors in Lipid Homeostasis
(Sponsored by the Divisions for Toxicology;
Clinical Pharmacology, Pharmacogenomics & Translational Medicine;
Cardiovascular Pharmacology; and Drug Metabolism)
Chair: Jean-Marc Pascussi and Curt J. Omiecinski
Convention Center, Room 208
Nuclear receptor regulation of bile acid
homeostasis.
John Chiang, Northeastern Ohio Universities College of
Medicine
Farnesoid X receptor modulates renal lipid
metabolism, fibrosis, and diabetic nephropathy.
Moshe Levi,
University of Colorado Health Sciences Center
The nuclear receptor CAR and its role in energy homeostasis.
Jodi Maglich, Pfizer Global R & D
Crosstalk of CAR and PXR activation as an effector of lipid metabolism
and glucose homeostasis.
Jean-Marc Pascussi, INSERM U632, Montpellier, France
The Role of
Insulin and Leptin in Drug Addiction and Mood
(Sponsored by the Divisions for Behavioral
Pharmacology; Neuropharmacology; and Systems & Integrative
Pharmacology)
Chairs: Charles P. France and Lynette C. Daws
Convention Center, Room 210
Insulin,
leptin, and food reward.
Dianne P. Figlewicz Lattemann, University of Washington
Health Science Center
The role of leptin signaling in emotional behavior.
Xin-Yun Lu, University of Texas Health Science Center at San
Antonio
DAT depends on what you eat: Neurochemical and behavioral
effects of amphetamine are dependent on insulin status.
Lynette C. Daws, University of Texas Health Science Center at San
Antonio
The role of leptin on human body weight regulation,
endocrine function, and neurobehavioral outcomes.
Gilberto Paz-Filho, University of Miami School of Medicine
Monday, April 20
9:55 - 12:30 PM
Tyrosine Kinases in Cancer
(Organized by ASBMB and co-sponsored by ASPET)
Chair: M.A. Lemmon
Convention Center, Room 357
Tyrosine kinase mechanisms and pathways
(Abstract 198.1)
P. Cole, Johns Hopkins University
Significance of activation loop phosphorylation in protein kinase A
studied by H/D exchange and X-ray crystallography (Abstract 709.9)
J.M. Steichen, M.P. Kuchinskas, G.H. Iyer, S. Li, V.L. Woods, S.S.
Taylor, UCSD
Negative cooperativity in the EGF receptor (Abstract 198.2)
L.J. Pike, Washington University School of Medicine
Rotation/twist model ofor the EGF/ErB receptor family activation
(Abstract 884.3)
I.N. Maruyama, Okinawa Institute of Science and
Technology
Erbb2/HER2/Neu resembles an autoinhibited invertebrate EGF receptor
(Abstract 884.3)
D. Alvarado, D.E. Klein, M.A. Lemmon, University of
Pennsylvania School of Medicine
Structural aspects of extracellular ECFR signaling (Abstract 198.3)
K.M. Ferguson, University of Pennsylvania School of Medicine
Monday, April 20
2:30 - 5:30 PM
Cardiovascular Pharmacology Division
Junior Scientists’ Competition and
Benedict R. Lucchesi Distinguished Award Lecture in Cardiac
Pharmacology
Chairs:
Brandon T. Larsen, Erin R. Harleton, and Biny K.
Joseph
Convention Center, Room 210
Introduction and recognition of
applicants
Brandon T. Larsen, Medical
College of Wisconsin
Graduate Student Presentations
Antiarrhythmic drug induced internalization of the atrial specific K+
channel, Kv1.5
S.M. Schumacher, University of Michigan (Advisor: J.R. Martens)
Cardiac myocyte-specific caveolin-3 overexpression modulates ANP
production and attenuates cardiac hypertropyhy in vivo
Y. Horikawa, UCSD (Advisor: D.M. Roth)
Thromboxane synthase inhibition blunts the development of pulmonary
hypertension and vascular remodeling in hypoxic neonatal piglets
D.K. Hirenallur-S., University of Arkansas for Medical Science
(Advisor: N.J. Rusch)
Insulin inhibitis low pO2-induced ATP release from human
erythrocytes (RBCs): Implications for vascular control in pre-diabetes
M. Hanson, St. Louis University (Advisor: R. Sprague)
Postdoctoral Scientist Presentations
Intracellular calcium silences L-type CA2+ channels in rat small
mesenteric veins
K. Thakali, University of Arkansas for Medical Science (Mentor:
N.J. Rusch)
GPR30 activation in salt-sensistive mRen2.Lewis females induces
beneficail effects independent of alterations in blood pressure
S.H. Lindsey, Wake Forest University School of Medicine
(Mentor: M.C. Chappell)
Graduate Student Runner-up Posters
Posters will be displayed by the three primary runners-up selected
on Sunday, April 19 at the Graduate Student-Postdoc Best Abstract
Competition
Postdoctoral Scientist Runner-up Poster
Engineered HGF/SF variants promote angiogenesis
S. Roy, Harvard-MIT Division of Health Science and Technology
(Mentor: S. Sengupta)
Benedict R. Lucchesi Distinguished Award Lecture in Cardiac
Pharmacology: Regulation of cardiac hypertrophy and heart
failure through Gq, calcium & CaM kinase II
Joan Heller Brown, UCSD
4:30 - 5:30 pm
Monday, April 20
3:00 - 5:30 PM
Behavioral Pharmacology Division
Symposium:
Pharmacological Imaging in Behavioral Pharmacology and Drug
Development
Chairs: Leonard L. Howell and Mike A. Nader
Convention Center, Room 207
Pharmacological MRI in
awake rats: application for drug discovery and development.
Chih-Liang Chin, Abbott Laboratories
Pharmacological MRI studies of the dopaminergic system in rhesus
monkeys.
Zhiming Zhang, University of Kentucky
Functional neuroimaging and cocaine medication development
in nonhuman primates.
Leonard L. Howell, Emory University
PET studies of stimulant drugs in humans.
Joanna S. Fowler, Brookhaven National Laboratories
Drug
Discovery, Development and Regulatory Affairs Division
Symposium: New Insights into Pain Signaling Pathways
Chairs: Anindya Bhattacharya and Mike F. Jarvis
Convention Center, Room 208
Cannabinoid
receptor signaling.
Kenneth Mackie, Indiana University;
Nav1.7 sodium channels: role in pain mechanisms and
targeting by neurotoxins.
Theodore
R. Cummins, Indiana University-Purdue University School of
Medicine;
Neuro-glial interactions in pain states: opportunities
for novel drug targets.
Joyce A.
Deleo, Dartmouth Medical School;
Calcitonin gene-related peptide (CGRP) receptor antagonists
for migraine - challenges and promises.
Christopher Salvatore, Merck Research Laboratories
GTP cyclohydrolase, tetrahydrobiopterin and pain.
Michael
L. Costigan, Harvard Medical School
Molecular
Pharmacology Division
Postdoctoral Award Finalists
Chair:
Michel Bouvier
Convention Center, Room 206
Protein kinase A and Epac are pro- and
anti-apoptotic mediators, respectively, in chronic lymphocytic leukemia
F. Murray, UCSD (Advisor: P. Insel)
Regulation of AGS3 and Giα 1 interaction in living cells.
S.S. Oner, Medical University of South Carolina (Advisor:
S. Lanier)
PKC α regulation of TRPM2 channel activation of Ca 2+ entry
in endothelial cells.
C. Hecquet, University of Illinois at Chicago (Advisor:
A. Malik)
Keynote Lecture: Ligand-biased signaling: Exploring
the molecular determinants of the multiple dimensions of drug efficacy
Michel M. Bouvier, University of Montréal
Toxicology
Division Symposium:
The
Nrf2-Keap1 System: An Emerging Key Regulator in the Defense Against
Oxidative Stress, Chemical Toxicity and Disease
Chair: Qiang Ma and Masayuki Yamamoto
Convention Center, Room 209
Nrf2: Key to
defense against oxidants, electrophiles, radiation and inflammation.
Paul Talalay, Johns Hopkins School of Medicine
Environmental lung disease and the role of Nrf2.
Steven R. Kleeberger,
NIEHS, NIH, Research Triangle Park, NC
Defense against toxic metals and hyperglycemia by Nrf2.
Qiang Ma, NIOSH, CDC
Nrf1 and Nrf2 interplay in regulation of stress response.
Jefferson Y. Chan, University of California-Irvine, School of
Medicine
Keynote
Address: Molecular basis
for the Nrf2-Keap1 system function.
Masayuki
Yamamoto,
Tohoku University School of Medicine, Sendai, Japan
Tuesday, April
21
8:00 - 10:00 AM
ASPET’s
Women in Pharmacology Committee and APS’ Women in Physiology
Committee Workshop:
Pathways to
Leadership: Developing Critical Skills
Chairs:
Andria Lee del Tredici, Holly Brevig, Barbara Alexander
Convention Center, Room 346
Opportunity knocks...(Should I answer?)
Kimberly E. Vanover, Intra-Cellular Therapeutics, Inc.
Surviving hurricane Katrina and embracing new chalenges.
Patricia Molina, LSU Health Science Center, New Orleans
Pleasures and perils of joint appointments
Alice M. Young, Texas Tech University Health Science Center
The long and winding road of career development
Lois D. Lehman-McKeeman, Bristol-Myers
Squibb
Tuesday, April
21
8:30 - 9:20 AM
TORALD SOLLMANN LECTURE
Convention Center, Room 206
Introduction: Joe A. Beavo
Mentors, Methods and Manuscripts
S. J. Enna,
University of Kansas Medical Center
Tuesday, April 21
9:30 - 12:00 PM
All
Presidents' Symposium on Integrative Pharmacology
(Sponsored by all ASPET Divisions)
Chair: Dennis C. Marshall and Bill W. Fleming
Convention Center, Room 206
From integrative to molecular pharmacology and back.
Elaine Sanders-Bush, Vanderbilt University Medical Center
Integrative pharmacology: The validation of biochemical and
molecular findings.
Sam J. Enna, University of Kansas Medical Center
Experimental basis of integrative pharmacology.
David B. Bylund, University of Nebraska Medical Center
Integrative pharmacological models in understanding
neuroplasticity.
James E. Barrett, Drexel University College of Medicine
Integrative pharmacology: Oxidative stress, gender and aging.
Sue P. Duckles, University of
California-Irvine, College of Medicine
Exposure to
Environmental Agent Alters Epigenetic Homeostasis
(Sponsored by the Divisions for Toxicology and
Drug Metabolism)
Chairs: Max Costa and Mary E. Vore
Convention Center, Room 208
Chromatin remodeling by chromium.
Alvaro Puga,
University of Cincinnati
Differentiation of ES cells induced by epigenetic regulation of
Pax6.
Luo Lu,
UCLA
Epigenetic effects of nickel exposure.
Max Costa, New York University School of Medicine
Identifying genome-wide DNA methylation patterns and histone
modifications in response to benzo[a]pyrene exposure.
David I. Rodenhiser,
University of Western Ontario
Programming ontogenic expression of P450 genes in mouse
liver development by epigenetic mechanisms.
Xiao-Boo Zhang, University of Kansas Medical Center
Discovery
and Development of Oligonucleotide Therapeutics
(Sponsored by the Divisions for Drug Discovery,
Drug Development & Regulatory Affairs and Molecular Pharmacology)
Chair: Tom J. Parry
Convention Center, Room 207
Oligonucleotide therapeutics: Past, present and future.
James
D. Thompson, Quark Pharmaceuticals, Inc.
Special issues in the discovery and development of RNAi
therapeutics.
Pamela A. Pavco, RXi Pharmaceuticals, Inc.,
Worcester,
MA
Progress in developing siRNAs as drugs. Christina Gamba-Vitalo, Alnylam Pharmaceuticals
Pharmacokinetics of oligonucleotide therapeutics.
Patrick L. Iversen,
AVI BioPharma, Inc.,Corvallis,
OR
Targeting
Drug Metabolizing Enzymes for Effective Chemopreventive Approaches
(Sponsored by the Divisions for Drug Metabolism;
Clinical Pharmacology, Pharmacogenomics & Translational Medicine;
Drug Discovery, Drug Development & Regulatory Affairs; Systems &
Integrative Pharmacology; and Toxicology)
Chairs: Hollie Swanson and Emily E. Scott
Convention Center, Room 209
Inhibitors of cytochrome P45017 alpha as agents for prostate cancer therapy.
Vincent C. Njar, University of Maryland School of Medicine
Chemoprevention of PAH-dependent transplacental cancer in a mouse model:
Role of Cyp1b1
David Williams, Oregon State University
Targeting Nrf2, phase I and phase II metabolizing enzymes for effective
chemoprevention strategies.
Ah-Ng Tony Kong, Rutgers University School of
Pharmacy
Cytochrome P450 prodrugs in cancer therapy - Targeting tumor cells and
tumor-associated endothelial cells.
David J. Waxman, Boston University
Receptor
Signaling and Regulation in Neuropsychiatric Research
(Sponsored by the Divisions for
Neuropharmacology; Behavioral Pharmacology; Molecular Pharmacology;
and ASBMB)
Chair:
Laura M. Bohn
Convention Center, Room 210
Fine tuning
receptor responsiveness.
Marc G. Caron, Duke University Medical Center
When two receptors become three.
Lakshmi Devi, Mount Sinai School of Medicine
Serotonin receptor signaling via ß-arrestins.
Laura M. Bohn, The Scripps Research Institute, Jupiter, FL
Dopamine receptor signaling via ß-arrestins.
Martin Beaulieu, University of Laval
Characterization of sorting nexin-25, a D1 and D2
dopamine receptor interacting protein that regulates receptor
expression and trafficking in HEK293 cells.
R.B. Free; Y. Namkung, L.A. Hazelwood, D.M. Cabrera, D.R. Sibley,
NINDS, NIH
Tuesday, April 21
2:00 - 5:30 PM
Drug
Metabolism Division
Early Career Achievement Award Lecture and Platform Session:
Biotransformation and Drug Transport
Chairs: Thomas Kocarek and Jeffrey Stevens
Convention Center, Room 209
Early Career Achievement Award Lecture:
Nuclear receptors in drug metabolism: A decade of orphan
brother actions.
Xie Wen, University of Pittsburgh
Contribution of the N-glucuronidation
pathway to the overall in vitro metabolic clearance of midazolam in humans
(Abstract 372.1)
S. Klieber, S. Hugla, R. Ngo, C. Arabeyre-Fabre, V. Meunier, F. Sadoun,
O. Fedeli, M. Rival, M. Bourrie, F. Guillou, P. Maurel, G. Fabre,
Sanofi-Aventis, Montpellier and Toulouse and INSERM U632, Montpelier
Kinetics and molecular interactions in the rapid disulfation of
raloxifene by human sulfotransferase 1E1 (Abstract 750.8)
I.T. Cook, S.N. Kadlubar, C.N. Falany, University
of Alabama at Birmingham and University of Arkansas for Medical Science
A cytochrome P450-derived epoxygenated metabolite of anandamide is a
potent, cannabinoid receptor 2 selective agonist (Abstract 749.4)
N.T. Snider, J.A. Nast, P.F. Hollenberg, University of
Michigan
Functional interactions between CYP1A2 and CYP2B4 require other enzymes
to reside in the same phospholipid vesicle (Abstract 749.3)
J.R. Reed, W.L. Backes, LSU Health Science Center, New Orleans
Association of breast cancer resistance protein/ABCG2 phenotypes and
novel promoter and intron 12 single nucleotide polymorphisms (Abstract
372.7)
B. Poonkuzhali, J. Lamba, S. Strom, S. Sparreboom, K. Thummel, Pl
Watkins, E. Schuetz, St. Jude Children's Research Hospital,
University of PIttsburgh, University of Washington and Univeristy of North
Carolina at Chapel Hill
Characterization of AS(GS)3 and (GS2AsSe) transport by the human
multidrug resistance portein 2 (MRP2/ABCC2) (Abstract 747.1)
M.W. Carew, E.M. Leslie, University of Alberta
Role of the Toll-like receptor adaptor protein, TIRAP in the regulation
of gene expression of hepatic drug metabolizing enzymes (Abstract 752.1)
R. Ghose, T. Guo, University of Houston
Dynamic DNA and histone methylation influences the ontogeny of
xenobiotic metabolizing genes during postnatal mouse liver maturation
(Abstract 752.4)
S.N. Hart, Y. Li, Y. Cui, C. Klaasen, X-b. Zhong, University of
Kansas Medical Center
Tuesday, April 21
3:00 - 5:30 PM
Neuroplastic and Neurodegenerative Changes
Associated with Drug Abuse and Addiction
(Sponsored by the Divisions for
Neuropharmacology; Behavioral Pharmacology; Systems & Integrative
Pharmacology; and Toxicology)
Chair: Jean Lud Cadet
Convention Center, Room 210
Clinical
neurobiology of marijuana addiction
K. Bolla, Johns Hopkins University
Transcriptional responses to reinforcing effects of cocaine in the
hippocampus and cortex.
Irina N. Krasnova,
NIDA, NIH
Biochemical and molecular consequences of repeated injections of
methamphetamine.
Jean Lud Cadet, NIDA, NIH
Role of microglial activation in drug-induced neurodegeneration.
Donald M. Kuhn, Wayne State University
Opiates, psychostimulants and adult hippocampal neurogenesis:
Insight for addiction.
Amelia Eisch, University of Texas Southwestern Medical Center
Clinical Pharmacology,
Pharmacogenomics and Translational Pharmacology Division Symposium:
Translational Clinical Pharmacology Research: Emerging Frontiers
Chair: Richard Kim
Convention Center, Room 207
In vivo probe drugs for assessing drug interaction potential for drugs
in development.
Joseph W. Polli, GlaxoSmithKline
Monitoring the anti-cancer effects and chemosensitizing abilities of
novel cyclotides from Psychotria Leptothyrsa (Abstract 756.10)
S.L. Gerlach, U. Göransson, D. Mondal, Tulane Univeristy
and Uppsala University, Sweden
Drug uptake transporters and cancer therapy: Bench to bedside.
Richard H. Ho, Vanderbilt University
Phosphodiesterase 7 (PDE&) and PDE4/7 inhibitors kill chronic
lymphocytic leukemia cells via a cAMP-mitochondrial-dependent pathway
(Abstract 761.10)
A.C. Zahno, F. Murray, L. Zhang, L. Rassenti, H. Cottam, T. Kipps,
P.A. Insel, UCSD
Delivery of Personalized Medicine: Examples from the University of Western
Ontario.
Richard B. Kim, University of Western Ontario
Neuropharmacology Division
Postdoctoral Scientist Award Finalists
Chair: Christian C. Felder
Convention Center, Room 206
Keynote Address:
Perspectives on the postdoctoral experience in the pharmaceutical industry
Christian C. Felder, Eli Lilly and Co.
Postdoctoral Scientist Award
Presentations
Caveats of proteomics approaches in identifying novel spinophilin
interacting proteins (Abstract 581.9)
A.J. Baucum II, A-J.L. Ham, R.J. Colbran, Vanderbilt University
Reduced microscopic GABAR sensitivity in rat hippocampal CA1 neurons
during benzodiazepine withdrawal is reversed by CaMKII inhibition (Abstract
760.13)
P. Das, L.J. Greenfield, Jr., E.I. Tietz, University of Toledo
College of Medicine
The cannabinoid CB1 receptor system modulates behavioral phenomena
predictive of relapse duing extinction of self-administration in mice
(Abstract 58837)
S.J. Ward, M. Rosenberg, L. Dykstra, E. Walker,
Temple
University School of Medicine and University of North Carolina at
Chapel Hill
Ex vivo and in vivo changes in function of the serotonin 2C recpetor due
to RNA editing (Abstract 842.2)
C.E. Canal, e. E. Watt, E. Sanders-Bush, Vanderbilt University
Beyond Prozac: generation and characterization of SSRI insensitive
transgenic mice (Abstract 942.7)
B.J. Thompson, T. Jessen, L.K. Henry, K.L. Gamble, P.J. Chisnell, D.G.
McMahon, R.D. Blakel, Vanderbilt University
and University of North Dakota
Systems and Integrative
Pharmacology Division
Young Investigator Platform
Chairs: David B. Bylund and Dennis C. Marshall
Convention Center, Room 208
Studies of tissue regeneration in a
rat bladder model in vivo (Abstract 939.1)
D. Burmeister, T. Aboushwareb, K-E. Andersson, G.J. Christ,
Wake Forest University School of Medicine
Does Caveolin-1 knockout affect matrix metalloproteinase-2 activity
and contractile function in the isolated working mouse heart? (Abstract
812.3)
A.K. Chow, E. Daniel, R. Schultz, University of Alberta
Molecular evidence for the involvement of calcium sensitization in
serotonin-induced cerebrovascular constriction (Abstract931.1)
A. El-Uazbi, R.P. Johnson, K. Takeya, E.J. Walsh, M.P. Walsh, W.C.
Cole, University of Calgary
Hypothalamic disinhibition stimulates retrotrapezoid nucleus
chemosensitive neurons in vivo (Abstract 946.2)
M.G. Fortuna, R.L. Stornetta, G.H. West, P.G. Guyenet,
University of Virginia
Distruption of the phosphodiesterase 8B gene alters the
hypothalamic-pituitary-adrenal axis (Abstract582.4)
L-C.L. Tsai, M. Shimizu-Albergine, J.A. Beavo, University of
Washington
CD38 prevents morphine-tolerance development in mouse distal colon
(Abstract 590.6)
G. Ross, W. Dewey, H. Akbarali, Virginia
Commonwealth University
COX mediates impaired estrogen-induced relaxation in resistance
arteries from postpartum rats (Abstract 932.3)
C.R. Royal and R.E. Whtie, Medical College of Georgia
Keynote Presentation: iPharm:
The key role of integrative pharmacology in 21st century drug
discovery
Michael Williams Cephalon, Inc.
Tuesday, April 21
3:30 - 6:00 PM
Transmembrane Signaling by GPCR
(Organized by ASBMB and co-sponsored by ASPET)
Chair: Heidi E. Hamm
Convention Center, Room 357
How do GPCRs catalyze G protein
activation? (Abstract 330.1)
H.E. Hamm, Vanderbilt University
Structure of an activated G protein-coupled receptor kinase reveals its
receptor-docking domain (Abstract 879.10)
J.J.G. Tesmer, P. Singh, C-c. Huang, University of Michigan
Two crystal structures of the beta2-adrenergic receptor (Abstract 330.2)
W.I. Weiss, Stanford University
Biased agonism reveals new G protein-independent AT 1a receptor signals
(Abstract 880.2)
R.T. Kendall, M-H. Lee, H.M. El-Shewy, M.G. Janceh, D.K. Luttrell, L.M.
Luttrell, Medical University of South Carolina and
Ralph H. Johnson VA Medical Center
GIV is a non-receptor GEF for Gαi
with a unique motif that regulates Akt signaling (Abstract 879.1)
M. Garcia-marcos, P. Ghosh, J. Ear, M.G. Farquhar, UCSD
G protein coupled receptor heterodimerization leads to distinct
signaling (Abstract 330.3)
L.A. Devi, Mount Sinai School of Medicine
Wednesday, April 22
8:00 - 10:30 AM
Virally-encoded G Protein Coupled Receptors as New Drug Targets?
(Sponsored by the Division for Molecular Pharmacology)
Chairs: Rob Leurs and Sergio Lira
Convention Center, Room 210
Viral mimicry of
G protein coupled receptor signaling.
Rob Leurs,
Vrije University, The Netherlands
HHV-8
encoded GPCR ORF74 and its role in viral oncogenesis.
J. Silvio Gutkind, NIDCR, NIH
HCMV-encoded GPCR US28 as oncomodulating GPCR
Maritne J. Smit, Vrije University, The Netherlands
Transgenic mouse models to dissect the role of viral GPCRs
in pathogenesis.
Sergio A. Lira, Mount Sinai School of Medicine
Functional analysis of HCMV-encoded GPCRs using mutant
CMV viruses.
William E. Miller, University of Cincinnati College of Medicine
Therapeutics in Autoimmunity: Treatment Successes and Side Effects
as a Tool of Elucidating Pathogenic Pathways
(Sponsored by the Committee on Women in
Pharmacology and the Divisions for Clinical Pharmacology,
Pharmacogenomics & Translational Medicine; Drug Discovery, Drug
Development & Regulatory Affairs; an Systems and Integrative
Pharmacology)
Chairs: Carol A. Paronis and Cornelia M. Weyand
Convention Center, Room 207
The making and
breaking of the immune system in rheumatoid arthritis - going
beyond anti-inflammatory therapy.
Cornelia M. Weyand, Emory University School of Medicine
Mechanisms of action of methotrexate in rheumatoid arthritis
- implications for understanding pathogenic pathways in
autoimmunity.
Bruce N. Cronstein, New York University School
of Medicine
Treating autoimmune arthritis through selective tyrosine
kinase inhibition.
William H. Robinson, Stanford University
Pharmacogenomics in rheumatoid arthritis - deciphering disease
pathways through better understanding of intended and unintended drug effects.
S. Lou Bridges, University of Alabama at Birmingham
Endothelial
Progenitor Cells and Cardiovascular Disease - From Bench to Bedside
(Sponsored by the Divisions for Systems &
Integrative Pharmacology; Cardiovascular Pharmacology; Drug
Discovery, Drug Development & Regulatory Affairs; and Molecular
Pharmacology)
Chair: Alex Chen
Convention Center, Room 208
Oxidative
stress and EPC dysfunction in salt-sensitive hypertension
Alex F. Chen, University of Pittsburgh
Role of osteopontin in EPC dysfunction in diabetes
mellitus.
Timothy O’Brien, National University of Ireland
EPC and vascular injury.
Zvonimir S. Katusic, Mayo Clinic and Foundation
EPC therapies for cardiovascular disease – current perspective.
Douglas W. Losordo, Northwestern University
Gases as
Neuromodulators in Sensing: From Nitric Oxide to Hydrogen Sulfide
(Sponsored by the Divisions for
Neuropharmacology; Cardiovascular Pharmacology; Molecular
Pharmacology; Systems & Integrative Pharmacology; and Toxicology)
Chair: Atsufumi Kawabata
and Philip K. Moore
Convention Center, Room 206
Neuronal
roles for gasotransmitters.
Phillip K. Moore, King’s College London
Roles for nitric oxide in itching and the development of
herpetic and postherpetic neuralgia.
Yasushi Kuraishi, University of Toyama
Hydrogen sulfide as a neuromodulator in the colon.
Michael Schemann, Technical University Munich
Hydrogen sulfide and pain
Atsufumi Kawabata,
Kinki University of Pharmacy, Higashi-Osaka
Exposure to nitrous oxide increases levels of nitric oxide
metabolites and ß-endorphin in ventricular cisternally-perfused
rats. (Abstract 742.3)
L.M. Zelinski, Y. Ohgami, R.M. Quock, Washington State
University
Nitroxyl (HNO) exerts antioxidant actions in carotid
arteries of mice (Abstract 936.5)
R.M. Ravi, A.A. Miller, M. Bullen, R.H. Ritchie, C.G. Sobey, B. K.
Kemp-Harper, Monash University and Baker IDI Heart &
Diabetes Institute, Melbourne, Australia
Regulation
of Xenobiotic Metabolizing Enzymes in Humans: Implications for the
Propagation of Health and Disease
(Sponsored by the Divisions for Drug Metabolism;
Clinical Pharmacology, Pharmacogenomics & Translational Medicine;
and Drug Discovery, Drug Development & Regulatory Affairs)
Chairs: Charles N. Falany and Melissa Runge-Morris
Convention Center, Room
209
Hepatic sterol metabolism: Regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) by nuclear receptor
networks.
Melissa Runge-Morris, Wayne State University
Genetic polymorphisms in human xenobiotic metabolizing enzymes
and cancer risk in steroidogenic tissues.
Susan A. Nowell Kadlubar, University of Arkansas for
Medical Sciences
Genetic polymorphisms affecting xenobiotic metabolism and
regulation: Implications for drug therapy and drug-drug
interactions in humans.
Erin G. Schuetz, St. Jude Children’s Research Hospital
Induction of sulfotransferase (SULT2B1b) expression in cystic fibrosis liver
disease.
Charles N. Falany, University of Alabama at Birmingham
Division
Sessions
Sunday, April 19
3:00 - 5:30 PM
Pharmacology Education Division Workshop:
Using Human Patient Simulators to Enhance Pharmacology Education
Throughout the Undergraduate Medical Curriculum
Chair: John
L. Szarek
Hilton Hotel, Melrose Room
Simulation has
been a mainstay in graduate medical education, but only recently has
it become more common in undergraduate medical education. This
workshop will help pharmacology faculty learn how simulation using
patient simulators can be used as part of their repertoire of
learning modalities for medical students in the first two years and
beyond. The workshop will include didactic and hands-on activities
on simulation modalities, the rationale for the use of simulation,
simulation as a complement to the basic science curriculum, and
scenario construction and debriefing.
Hands on
experience using a human patient simulator.
Facilitators: John L. Szarek, AT Still
University and Robert J. Theobald, Jr., AT Still
University, Kirksville, MO
The rationale
for the use of simulation as a complement to the basic science
curriculum.
John L. Szarek, AT Still University
Scenario construction and debriefing.
Susan Pasquale,
University of Massachusetts Medical School
Adoption and implementation strategies (and coping strategies
for dealing with barriers) that could be used to support using
simulation for teaching pharmacology throughout the undergraduate
curriculum.
William B. Jeffries, Creighton University School of Medicine
Monday, April 20
2:30 - 5:30 PM
Cardiovascular Pharmacology Division
Junior Scientists’ Competition and
Benedict R. Lucchesi Distinguished Award Lecture in Cardiac
Pharmacology
Chairs:
Brandon T. Larsen, Erin R. Harleton, and Biny K.
Joseph
Convention Center, Room 210
Introduction and recognition of
applicants
Brandon T. Larsen, Medical
College of Wisconsin
Graduate Student Presentations
Antiarrhythmic drug induced internalization of the atrial specific K+
channel, Kv1.5
S.M. Schumacher, University of Michigan (Advisor: J.R. Martens)
Cardiac myocyte-specific caveolin-3 overexpression modulates ANP
production and attenuates cardiac hypertropyhy in vivo
Y. Horikawa, UCSD (Advisor: D.M. Roth)
Thromboxane synthase inhibition blunts the development of pulmonary
hypertension and vascular remodeling in hypoxic neonatal piglets
D.K. Hirenallur-S., University of Arkansas for Medical Science
(Advisor: N.J. Rusch)
Insulin inhibitis low pO2-induced ATP release from human
erythrocytes (RBCs): Implications for vascular control in pre-diabetes
M. Hanson, St. Louis University (Advisor: R. Sprague)
Postdoctoral Scientist Presentations
Intracellular calcium silences L-type CA2+ channels in rat small
mesenteric veins
K. Thakali, University of Arkansas for Medical Science (Mentor:
N.J. Rusch)
GPR30 activation in salt-sensistive mRen2.Lewis females induces
beneficail effects independent of alterations in blood pressure
S.H. Lindsey, Wake Forest University School of Medicine
(Mentor: M.C. Chappell)
Graduate Student Runner-up Posters
Posters will be displayed by the three primary runners-up selected
on Sunday, April 19 at the Graduate Student-Postdoc Best Abstract
Competition
Postdoctoral Scientist Runner-up Poster
Engineered HGF/SF variants promote angiogenesis
S. Roy, Harvard-MIT Division of Health Science and Technology
(Mentor: S. Sengupta)
Benedict R. Lucchesi Distinguished Award Lecture in Cardiac
Pharmacology: Regulation of cardiac hypertrophy and heart
failure through Gq, calcium & CaM kinase II
Joan Heller Brown, UCSD
Monday, April 20
3:00 - 5:30 PM
Molecular
Pharmacology Division
Postdoctoral Award Finalists
Chair:
Michel Bouvier
Convention Center, Room 206
Protein kinase A and Epac are pro- and
anti-apoptotic mediators, respectively, in chronic lymphocytic leukemia
F. Murray, UCSD (Advisor: P. Insel)
Regulation of AGS3 and Giα 1 interaction in living cells.
S.S. Oner, Medical University of South Carolina (Advisor:
S. Lanier)
PKC α regulation of TRPM2 channel activation of Ca 2+ entry
in endothelial cells.
C. Hecquet, University of Illinois at Chicago (Advisor:
A. Malik)
Keynote Lecture: Ligand-biased signaling: Exploring
the molecular determinants of the multiple dimensions of drug efficacy
Michel M. Bouvier, University of Montréal
Drug
Discovery, Development and Regulatory Affairs Division
Symposium: New Insights into Pain Signaling Pathways
Chairs: Anindya Bhattacharya and Mike F. Jarvis
Convention Center, Room 208
Cannabinoid
receptor signaling.
Kenneth Mackie, Indiana University;
Nav1.7 sodium channels: role in pain mechanisms and
targeting by neurotoxins.
Theodore
R. Cummins, Indiana University-Purdue University School of
Medicine;
Neuro-glial interactions in pain states: opportunities
for novel drug targets.
Joyce A.
Deleo, Dartmouth Medical School;
Calcitonin gene-related peptide (CGRP) receptor antagonists
for migraine - challenges and promises.
Stefanie A.
Kane, Merck Research Laboratories
GTP cyclohydrolase, tetrahydrobiopterin and pain.
Michael
L. Costigan, Harvard Medical School
Toxicology
Division Symposium:
The
Nrf2-Keap1 System: An Emerging Key Regulator in the Defense Against
Oxidative Stress, Chemical Toxicity and Disease
Chair: Qiang Ma
Convention Center, Room 209
Nrf2: Key to
defense against oxidants, electrophiles, radiation and inflammation.
Paul Talalay, Johns Hopkins School of Medicine
Environmental lung disease and the role of Nrf2.
Steven R. Kleeberger,
NIEHS, NIH, Research Triangle Park, NC
Defense against toxic metals and hyperglycemia by Nrf2.
Qiang Ma, NIOSH, CDC
Nrf1 and Nrf2 interplay in regulation of stress response.
Jefferson Y. Chan, University of California-Irvine, School of
Medicine
Keynote
Address: Molecular basis
for the Nrf2-Keap1 system function.
Masayuki
Yamamoto,
Tohoku University School of Medicine, Sendai, Japan
Behavioral Pharmacology Division
Symposium:
Pharmacological Imaging in Behavioral Pharmacology and Drug
Development
Chairs: Leonard L. Howell and Mike A. Nader
Convention Center, Room 207
Pharmacological MRI in
awake rats: application for drug discovery and development.
Chih-Liang Chin, Abbott Laboratories
Pharmacological MRI studies of the dopaminergic system in rhesus
monkeys.
Zhiming Zhang, University of Kentucky
Functional neuroimaging and cocaine medication development
in nonhuman primates.
Leonard L. Howell, Emory University
PET studies of stimulant drugs in humans.
Joanna S. Fowler, Brookhaven National Laboratories
Tuesday, April 21
2:00 - 5:30 PM
Drug
Metabolism Division
Early Career Achievement Award Lecture and Platform Session:
Biotransformation and Drug Transport
Chairs: Thomas Kocarek and Jeffrey Stevens
Convention Center, Room 209
Early Career Achievement Award Lecture:
Nuclear receptors in drug metabolism: A decade of orphan
brother actions.
Xie Wen, University of Pittsburgh
Contribution of the N-glucuronidation
pathway to the overall in vitro metabolic clearance of midazolam in humans
(Abstract 372.1)
S. Klieber, S. Hugla, R. Ngo, C. Arabeyre-Fabre, V. Meunier, F. Sadoun,
O. Fedeli, M. Rival, M. Bourrie, F. Guillou, P. Maurel, G. Fabre,
Sanofi-Aventis, Montpellier and Toulouse and INSERM U632, Montpelier
Kinetics and molecular interactions in the rapid disulfation of
raloxifene by human sulfotransferase 1E1 (Abstract 750.8)
I.T. Cook, S.N. Kadlubar, C.N. Falany, University
of Alabama at Birmingham and University of Arkansas for Medical Science
A cytochrome P450-derived epoxygenated metabolite of anandamide is a
potent, cannabinoid receptor 2 selective agonist (Abstract 749.4)
N.T. Snider, J.A. Nast, P.F. Hollenberg, University of
Michigan
Functional interactions between CYP1A2 and CYP2B4 require other enzymes
to reside in the same phospholipid vesicle (Abstract 749.3)
J.R. Reed, W.L. Backes, LSU Health Science Center, New Orleans
Association of breast cancer resistance protein/ABCG2 phenotypes and
novel promoter and intron 12 single nucleotide polymorphisms (Abstract
372.7)
B. Poonkuzhali, J. Lamba, S. Strom, S. Sparreboom, K. Thummel, Pl
Watkins, E. Schuetz, St. Jude Children's Research Hospital,
University of PIttsburgh, University of Washington and Univeristy of North
Carolina at Chapel Hill
Characterization of AS(GS)3 and (GS2AsSe) transport by the human
multidrug resistance portein 2 (MRP2/ABCC2) (Abstract 747.1)
M.W. Carew, E.M. Leslie, University of Alberta
Role of the Toll-like receptor adaptor protein, TIRAP in the regulation
of gene expression of hepatic drug metabolizing enzymes (Abstract 752.1)
R. Ghose, T. Guo, University of Houston
Dynamic DNA and histone methylation influences the ontogeny of
xenobiotic metabolizing genes during postnatal mouse liver maturation
(Abstract 752.4)
S.N. Hart, Y. Li, Y. Cui, C. Klaasen, X-b. Zhong, University of
Kansas Medical Center
Tuesday, April 21
3:00 - 5:30 PM
Clinical Pharmacology,
Pharmacogenomics and Translational Pharmacology Division Symposium:
Translational Clinical Pharmacology Research: Emerging Frontiers
Chair: Richard Kim
Convention Center, Room 207
In vivo probe drugs for assessing drug interaction potential for drugs
in development.
Joseph W. Polli, GlaxoSmithKline
Monitoring the anti-cancer effects and chemosensitizing abilities of
novel cyclotides from Psychotria Leptothyrsa (Abstract 756.10)
S.L. Gerlach, U. Göransson, D. Mondal, Tulane Univeristy
and Uppsala University, Sweden
Drug uptake transporters and cancer therapy: Bench to bedside.
Richard H. Ho, Vanderbilt University
Phosphodiesterase 7 (PDE&) and PDE4/7 inhibitors kill chronic
lymphocytic leukemia cells via a cAMP-mitochondrial-dependent pathway
(Abstract 761.10)
A.C. Zahno, F. Murray, L. Zhang, L. Rassenti, H. Cottam, T. Kipps,
P.A. Insel, UCSD
Delivery of Personalized Medicine: Examples from the University of Western
Ontario.
Richard B. Kim, University of Western Ontario
Systems and Integrative
Pharmacology Division
Young Investigator Platform
Chairs: David B. Bylund and Dennis C. Marshall
Convention Center, Room 208
Studies of tissue regeneration in a
rat bladder model in vivo (Abstract 939.1)
D. Burmeister, T. Aboushwareb, K-E. Andersson, G.J. Christ,
Wake Forest University School of Medicine
Does Caveolin-1 knockout affect matrix metalloproteinase-2 activity
and contractile function in the isolated working mouse heart? (Abstract
812.3)
A.K. Chow, E. Daniel, R. Schultz, University of Alberta
Molecular evidence for the involvement of calcium sensitization in
serotonin-induced cerebrovascular constriction (Abstract931.1)
A. El-Uazbi, R.P. Johnson, K. Takeya, E.J. Walsh, M.P. Walsh, W.C.
Cole, University of Calgary
Hypothalamic disinhibition stimulates retrotrapezoid nucleus
chemosensitive neurons in vivo (Abstract 946.2)
M.G. Fortuna, R.L. Stornetta, G.H. West, P.G. Guyenet,
University of Virginia
Distruption of the phosphodiesterase 8B gene alters the
hypothalamic-pituitary-adrenal axis (Abstract582.4)
L-C.L. Tsai, M. Shimizu-Albergine, J.A. Beavo, University of
Washington
CD38 prevents morphine-tolerance development in mouse distal colon
(Abstract 590.6)
G. Ross, W. Dewey, H. Akbarali, Virginia
Commonwealth University
Keynote Presentation: iPharm:
The key role of integrative pharmacology in 21st century drug
discovery
Michael Williams Cephalon, Inc.
Neuropharmacology Division
Postdoctoral Scientist Award Finalists
Chair: Christian C. Felder
Convention Center, Room 206
Keynote Address:
Perspectives on the postdoctoral experience in the pharmaceutical industry
Christian C. Felder, Eli Lilly and Co.
Postdoctoral Scientist Award
Presentations
Caveats of proteomics approaches in identifying novel spinophilin
interacting proteins (Abstract 581.9)
A.J. Baucum II, A-J.L. Ham, R.J. Colbran, Vanderbilt University
Reduced microscopic GABAR sensitivity in rat hippocampal CA1 neurons
during benzodiazepine withdrawal is reversed by CaMKII inhibition (Abstract
760.13)
P. Das, L.J. Greenfield, Jr., E.I. Tietz, University of Toledo
College of Medicine
The cannabinoid CB1 receptor system modulates behavioral phenomena
predictive of relapse duing extinction of self-administration in mice
(Abstract 58837)
S.J. Ward, M. Rosenberg, L. Dykstra, E. Walker, Temple
University School of Medicine and University of North Carolina at
Chapel Hill
Ex vivo and in vivo changes in function of the serotonin 2C recpetor due
to RNA editing (Abstract 842.2)
C.E. Canal, e. E. Watt, E. Sanders-Bush, Vanderbilt University
Beyond Prozac: generation and characterization of SSRI insensitive
transgenic mice (Abstract 942.7)
B.J. Thompson, T. Jessen, L.K. Henry, K.L. Gamble, P.J. Chisnell, D.G.
McMahon, R.D. Blakel, Vanderbilt University
and University of North Dakota
Lectures
Sunday, April 19
8:30 - 9:20 AM
RAY FULLER LECTURE IN THE NEUROSCIENCES
Convention
Center, Room 206
Lecturer: Henry A. Lester,
Caltech
Changes in the
Brain During Chronic Exposure to Nicotine
Sunday, April 19
2:00 - 2:50 PM
IUPHAR
LECTURE
Convention Center, Room 206
Lecturer:
Robert Lefkowitz,
Duke University
Seven
Transmembrane Receptors
Monday, April 20
8:30 - 9:20 AM
JULIUS
AXELROD AWARD LECTURE
Convention Center, Room 206
Lecturer: Randy D.
Blakely, Vanderbilt University
Miscarriage at the Synapse: Brain Disorder-associated Deficits in
Membrane
Transport
Monday, April 20
4:30 - 5:30 PM
BENEDICT R.
LUCCHESI DISTINGUISHED AWARD LECTURE IN CARDIAC PHARMACOLOGY
Convention Center, Room 210
Lecturer: Joan Heller Brown, University of
California, San Diego
Regulation of Cardiac Hypertrophy and Heart Failure through Gq,
Calcium and CaM Kinase II
Tuesday, April 21
8:30 - 9:20 AM
TORALD
SOLMANN AWARD LECTURE
Convention Center, Room 206
Lecturer: Sam J. Enna, University of Kansas
Medical Center
Mentors, Methods and Manuscripts
Tuesday, April 21
2:00 - 2:50 PM
DRUG METABOLISM EARLY CAREER ACHIEVEMENT
AWARD LECTURE
Convention Center, Room 209
Lecturer: Wen Xie, University of
Pittsburgh
Nuclear Receptors in Drug Metabolism: A Decade of
Orphan Brother Actions
Special Sessions
Saturday, April
18
12:30 - 3:00 PM
2009
Teaching Institute:
Threading New Concepts into Existing Curriculum: Experiences with Genomics
Chair: George A. Dunaway
Convention Center, Room 207
Curricular threads in medical school curricula.
Phillip R. Musich, East Tennessee State University
Experience with introduction of genomics into medical biochemistry.
Phillip R. Musich, East Tennessee State University
Experience with introduction of genomics into medical pharmacology.
George A. Dunaway, Southern Illinois University
Development and use of clinical scenarios to introduce pharmacogenomics.
George A. Dunaway, Southern Illinois University
Resources for learning and curricular integration of genomics.
Phillip R. Musich, East Tennessee State University
Diversity
Committee Symposium:
ASPET Travel Fellows: Lessons Learned Along the Way:
Career Choices from
Past Travel Awardees
Chairs: Gonzalo E. Torres and Dolores Shockley
Convention Center, Room 208
The goal of this symposium is to present
and discuss career options taken by past fellows and travel awardees. The
stories are of scientists who made the decision to either stay in academia or
leave academic research and forged paths to alternative career options related
to science. These stories will focus on how these scientists got to where they
are today and what they have learned along the way. After the talks, there will
be an open session with questions and discussion from the audience.
Career options in science.
Gonzalo E. Torres, University of Pittsburgh
A career path outside the bench as a medical science liaison.
Shola Adewale, Eisia Inc.
Scientific regulatory and policy writing in the government: Desktop, an
alternative to Benchtop.
Michelle D. Walker, Drug Enforcement Administration
Career opportunities in biomedical research: The academic perspective.
Chantal A. Rivera, Louisiana State University Health Sciences
Center
Closing remarks
Dolores C. Shockley, Meharry Medical College
3:15 - 5:45 PM
Graduate
Student-Postdoctoral Colloquium:
Mentoring: It Goes Both Ways
Chair: Sarah H. Lindsey
Convention Center, Room 209
The success of graduate or
post-graduate research experiences depends largely on a positive relationship
between the trainee and mentor. This colloquium, based on a program developed
by Chris Pfund at the Wisconsin Program for Scientific Teaching, is focused on
helping participants improve the efficiency and effectiveness of their current
mentor/mentee relationship and learn how to become effective research mentors
themselves. Discussions will focus on different mentoring styles and strategies
for developing confidence and independence, establishing expectations and
improving communication skills.
Entering mentoring: Learning to become an effective research mentor.
Chris E. Pfund, University of
Wisconsin Program for
Scientific Teaching
Session 1: Learning to communicate
Session 2: Goals and expectations
Session 3: The elements of good mentoring
Pulling it all together: Pharmacologists helping pharmacologists.
Stephanie Watts, Michigan State University
Tuesday, April
21
8:00 - 10:00 AM
ASPET’s
Women in Pharmacology Committee and APS’ Women in Physiology
Committee Workshop:
Pathways to
Leadership: Developing Critical Skills
Chairs:
Andria Lee del Tredici, Holly Brevig, Barbara Alexander
Convention Center, Room 346
Opportunity knocks...(Should I answer?)
Kimberly E. Vanover, Intra-Cellular Therapeutics, Inc.
Surviving hurricane Katrina and embracing new chalenges.
Patricia Molina, LSU Health Science Center, New Orleans
Pleasures and perils of joint appointments
Alice M. Young, Texas Tech University Health Science Center
The long and winding road of career development
Lois D. Lehman-McKeeman, Bristol-Myers
Squibb
Satellite Meetings
FRIDAY & SATURDAY, April
17-18
G-Protein
Targets Colloquium
Room: Convention Center 204
A/B/C
(Separate, Advance Registration
Required)
Chairs: Alan V. Smrcka and
Theresa Filtz
SATURDAY,
April 18
Behavioral Pharmacology Society Meeting
Room: Convention Center 201
(Separate, Advance Registration
Required)
Contact
Nancy Ator:
ator@jhmi.edu or 410-550-2773
Public
Affairs Session
EB
2008 Public Affairs Session
Monday, April 20
5:00 - 6:30 pm
Evolution of
Creationism
(Co-Sponsors: ASPET, ASBMB and APS)
Convention Center, La Louisiane Ballroom
Speakers
Chair, Greg Petsko, Brandeis University
Barbara Forrest,
Southeastern Louisiana University, author of Creationism’s Trojan
Horse
Judge John E. Jones,
Federal Judge who presided at the Kitzmiller v. Dover trial in 2005
Ken Miller,
Brown University, author of Finding Darwin’s God and other books
on the battle over teaching evolution
Eugenie Scott,
Executive Director of the National Center for Science Education,
Oakland, California, and author of
Evolution versus Creationism (a second edition of which is soon
to be published)
Public
Affairs Symposium
Monday, April 20
5:45 - 7:15 pm
Improving NIH Peer Review: Maintaining the National
Strategic Value of Peer Review
Sponsored by APS, AAA, ASPET
Convention Center, Room 255/256/257
Chair: V.M. Miller
Speaker: Tony Scarpa, CSR, NIH
General Information
Awards
Call for Abstracts
Hotels
Registration
|
